Gas Chromatography with Modified pH-Sensitive Pellets in Evaluating Esterase Activity of Carbonic Anhydrase III Enzyme: Drug Discovery Approach
Abstract
Antagonism of carbonic anhydrase, isozyme 3 (CAIII) has a strong potential in treating obesity, hyperlipidemia and cancer. The enzyme has a very low activity in hydrating carbon dioxide which makes it unresponsive to the majority of methods used against other CAs. In this study, a new evaluation method based on gas chromatography (GC) is considered for the screening of the inhibitory activity of various nicotinic acid derivatives against CAIII...
Paper Details
Title
Gas Chromatography with Modified pH-Sensitive Pellets in Evaluating Esterase Activity of Carbonic Anhydrase III Enzyme: Drug Discovery Approach
Published Date
Oct 22, 2021
Journal
Volume
84
Issue
12
Pages
1113 - 1120
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