De novo endocytic clathrin coats develop curvature at early stages of their formation
Abstract
Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation on the cell surface, which is the primary function of the endocytosis machinery. Using super-resolved live cell fluorescence imaging, we demonstrate that curvature generation by individual clathrin-coated pits can be detected in real time within cultured cells and tissues of developing organisms. Our analyses demonstrate that the footprint of clathrin...
Paper Details
Title
De novo endocytic clathrin coats develop curvature at early stages of their formation
Published Date
Nov 1, 2021
Journal
Volume
56
Issue
22
Pages
3146 - 3159.e5
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