Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations
Abstract
We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alexa Fluor 647 and TAMRA fluorophores and coupling...
Paper Details
Title
Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations
Published Date
Nov 16, 2021
Journal
Volume
32
Issue
12
Pages
2507 - 2515
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