A synthesis of pyrazino[1,2-a]indoles via one-pot cascade Ugi condensation and N-annulation under mild conditions
Abstract
A novel, one-pot, mild and operationally simple synthetic approach for the synthesis of pyrazino[1,2-a]indole derivatives is reported. The reaction proceeds via a 4-component Ugi condensation followed by N-annulation of the intermediate to afford the titled product under metal and acid-free conditions in methanol. The procedure consists of one-step tandem condensation and cyclization of Indole-2-carboxylic acid with isocyanides, phenacylamine...
Paper Details
Title
A synthesis of pyrazino[1,2-a]indoles via one-pot cascade Ugi condensation and N-annulation under mild conditions
Published Date
Dec 1, 2021
Journal
Volume
87
Pages
153547 - 153547
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