METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression
Abstract
N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 play an important role in tumorigenesis of a series of tumors. However, dysregulation of METTL3 in gallbladder cancer (GBC) remains obscure. Here, we showed that upregulated METTL3 level predicted poor prognosis and correlated with increased lymphatic metastasis and high TNM stage. Functionally, we found that METTL3 could promote cell proliferation, invasion,...
Paper Details
Title
METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression
Published Date
Nov 19, 2021
Journal
Volume
29
Issue
7
Pages
1012 - 1020
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Notes
History