Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis

•Sox9 is required for Yap-induced hepatocyte plasticity during hepatocarcinogenesis in mice. •Sox9 removal in hepatocytes with Yap activation resulted in more aggressive HCC. •Sox9 expression is sufficient to promote cell fate plasticity in less differentiated hepatocytes in vivo. •YAP activity and SOX9 expression are strongly correlated with liver tumor plasticity in human patients. Background & Aims Primary liver tumors comprise distinct...