Intravenous fluid therapy in the intensive care unit: Back to BaSICS?

Our understanding of chronic inflammation in obesity is evolving. Suggested mechanisms include hypoxia of adipose tissue and a subsequent increase in circulating cytokines. It is now known that adipose tissue, far from being an inert tissue, produces and secretes multiple peptides that influence inflammation and metabolism, including substrates of the renin–angiotensin–aldosterone system (RAAS). RAAS blocking antihypertensive medication and...