Clotrimazole-loaded fatty acid-based in situ forming film oral spray

• In situ forming film (ISF) oral spray solutions contain lauric acid and clove oil in N -methyl pyrrolidone. • Higher lauric acid amount decreased density, pH and contact angle while increased gelation and matrix film formation. • Clotrimazole-loaded ISF oral spray exhibited a gelation at once upon contacted with phosphate buffer pH 6.8. • Lower viscosity of ISF has been interested as oral spray owing to ease of spraying. • Matrix film of...