Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants
Abstract
Importance
Single-blind placebo run-in (PRI) periods are common in randomized clinical trials (RCTs) of treatment for depression. They aim to increase sensitivity to detect drug effects; however, the association of PRI periods with study outcomes remains unclear. This is concerning given the costs of PRI periods to patients and investigators.Objective
To examine the association of the use of PRI periods with the placebo...Paper Details
Title
Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants
Published Date
Jan 1, 2022
Journal
Volume
79
Issue
1
Pages
42 - 42
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Notes
History