Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation
Abstract
The early development of many organisms involves the folding of cell monolayers, but this behaviour is difficult to reproduce in vitro; therefore, both mechanistic causes and effects of local curvature remain unclear. Here we study epithelial cell monolayers on corrugated hydrogels engineered into wavy patterns, examining how concave and convex curvatures affect cellular and nuclear shape. We find that substrate curvature affects monolayer...
Paper Details
Title
Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation
Published Date
Nov 18, 2021
Journal
Volume
17
Issue
12
Pages
1382 - 1390
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History