Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis

There is growing evidence supporting the efficacy of shorter courses of antibiotic therapy for common infections. However, the risks of prolonged antibiotic duration are underappreciated.To estimate the incremental daily risk of antibiotic-associated harms.We searched three major databases to retrieve systematic reviews from 2000 to 30 July 2020 in any language.Systematic reviews were required to evaluate shorter versus longer antibiotic therapy...