Clinical and genomic features of SPOP‐mutant prostate cancer

Background Inactivating missense mutations in the SPOP gene, encoding speckle‐type poxvirus and zinc‐finger protein, are one of the most common genetic alterations in prostate cancer. Methods We retrospectively identified 72 consecutive prostate cancer patients with somatic SPOP mutations, through next‐generation sequencing analysis, who were treated at the Johns Hopkins Hospital. We evaluated clinical and genomic characteristics of this SPOP...