ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma

Volume: 22, Issue: 1
Published: Nov 11, 2021
Abstract
Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic, predictive of response to chemotherapy, and correlate with distinct tumor microenvironments.To reconcile these findings, we profile 22 human IDH-mutant gliomas using scATAC-seq and scRNA-seq. We determine the...
Paper Details
Title
ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma
Published Date
Nov 11, 2021
Volume
22
Issue
1
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.