Selection for phage resistance reduces virulence of Shigella flexneri .
Abstract
There is increasing interest in phage therapy as an alternative to antibiotics for treating bacterial infections, especially using phages that select for evolutionary trade-offs between increased phage resistance and decreased fitness traits such as virulence in target bacteria. A vast repertoire of virulence factors allows the opportunistic bacterial pathogen, Shigella flexneri , to invade human gut epithelial cells, replicate intracellularly,...
Paper Details
Title
Selection for phage resistance reduces virulence of Shigella flexneri .
Published Date
Nov 17, 2021
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