Shikonin alleviates choroidal neovascularization by inhibiting proangiogenic factor production from infiltrating macrophages
Abstract
Choroidal neovascularization (CNV), a feature of neovasular age-related macular degeneration (AMD), acts as a leading cause of vision loss in the elderly. Shikonin (SHI), a natural bioactive compound extracted from Chinese herb radix arnebiae, exerts anti-inflammatory and anti-angiogenic roles and also acts as a potential pyruvate kinase M2 (PKM2) inhibitor in macrophages. The major immune cells macrophages infiltrate the CNV lesions, where the...
Paper Details
Title
Shikonin alleviates choroidal neovascularization by inhibiting proangiogenic factor production from infiltrating macrophages
Published Date
Dec 1, 2021
Journal
Volume
213
Pages
108823 - 108823
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