Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
Abstract
Abivertinib, a third-generation tyrosine kinase inhibitor, is originally designed to target epidermal growth factor receptor (EGFR)-activating mutations. Previous studies have shown that abivertinib has promising antitumor activity and a well-tolerated safety profile in patients with non-small-cell lung cancer. However, abivertinib also exhibited high inhibitory activity against Bruton’s tyrosine kinase and Janus kinase 3. Given that these...
Paper Details
Title
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
Published Date
Nov 18, 2021
Journal
Volume
16
Issue
3
Pages
416 - 428
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Notes
History