Design and validation of a synchrotron proton beam line for FLASH radiotherapy preclinical research experiments

Purpose The main purpose of this work was to generate and validate the dosimetric accuracy of proton beams of dimensions that are appropriate for in vivo small animal and in vitro ultrahigh dose rate (FLASH) radiotherapy experiments using a synchrotron‐based treatment delivery system. This study was performed to enable future investigations of the relevance of a spread‐out Bragg peak (SOBP) under FLASH conditions. Methods The spill...