Biotransformation and Quantification of Sinensetin and Its Metabolites in Plasma, Urine, and Feces of Rats

As one of the major polymethoxyflavones in citrus peels, sinensetin (Sin) has been reported to possess numerous bioactivities. However, its detailed in vivo metabolic fate has not been uncovered yet. In the present study, the possible metabolites of Sin were synthesized, and all five mono-demethylated metabolites were successfully identified via ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis in rats fed...