Synthesis, in vitro antimicrobial evaluation, and molecular docking studies of new isatin-1,2,3-triazole hybrids

Antibiotic resistance is rapidly evolving at an alarming rate, posing a severe threat to humanity. In an effort to develop compounds with antimicrobial activity, we synthesized a series of isatin-1,2,3-triazole hybrids 12–21 using the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. Structural verification of the new isatin-1,2,3-triazole hybrids was accomplished using a variety of spectroscopic characterization techniques. The...