Exploring the Bioactive Sites of New Sulfonamide Metal Chelates for Multi-Drug Resistance: An Experimental Versus Theoretical Design

During this report, the synthesis, characterization, medicinal, and molecular modeling of newly synthesized, bidentate sulfonamide metal (VO2+, Co2+, Ni2+, Cu2+, and Zn2+) chelates are consulted. The octahedral geometry is assigned to all the metal chelates except the oxo-vanadium compouns having square pyramidal arrangement. The geometry optimization and other theoretical studies are performed by Density Functional Theory (DFT) techniques by...