Dynamic flow enables long‐term maintenance of 3‐D vascularized human skin models

Approaches to develop three-dimensional (3-D) vascularized human skin equivalents (vHSEs) that can mimic native skin are currently gaining momentum. Yet, the reproducible fabrication of vHSEs with superior barrier properties, sustained vasculature and high durability remains a challenge. Here, we aim to improve the stability of scaffold-free vHSEs by utilizing a dynamic flow culture system. We established that in static vHSEs, the uncontrolled...