Dynamic Tumor Mutational Profiling Using a Novel Non-Invasive Swab Technique for Serial Whole Exome Sequencing of Cervical Tumors During Chemoradiation Therapy

Purpose/Objective(s)Clinically relevant genetic predictors of radiation response for cervical cancer are understudied due to the morbidity of repeat invasive biopsies required to obtain genetic material. We have developed a novel noninvasive cervical swab technique to collect tumor DNA with adequate throughput to perform whole exome sequencing (WES) at serial timepoints over the course of chemoradiation therapy (CRT). We hypothesize that...