Evaluating pediatric and adult simulated fluids solubility: Abraham solvation parameters and multivariate analysis

To understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in pediatric patients. To assess the discrimination ability of the Abraham solvation parameters and age-related changes in simulated media composition to predict in vitro drug solubility differences between pediatric and adult gastrointestinal conditions by multivariate data analysis.Differences between drug solubility in pediatric and...