Silica Induced Lung Fibrosis Is Associated With Senescence, Fgr, and Recruitment of Bone Marrow Monocyte/Macrophages

Volume: 35, Issue: 6, Pages: 3053 - 3066
Published: Jan 1, 2021
Abstract
The role of senescence and bone marrow-derived cells in silica-induced pulmonary fibrosis is unknown.C57BL/6HNsd, p16+/LUC, and tdTOMp16+ mice were intratracheally injected with 200 mg/kg crystalline silica or irradiated (20 Gy) to the thoracic cavity and followed for the development of lung fibrosis.The p16+/LUC mice demonstrated senescence by day 7 after silica exposure. C57BL/6 mice exposed to silica demonstrated upregulation of p16, p21, and...
Paper Details
Title
Silica Induced Lung Fibrosis Is Associated With Senescence, Fgr, and Recruitment of Bone Marrow Monocyte/Macrophages
Published Date
Jan 1, 2021
Journal
Volume
35
Issue
6
Pages
3053 - 3066
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