Virology

Outbreak

Philosophy

Prospective cohort study

Foot-and-mouth disease

Epidemiology

Hand-foot-and-mouth disease

Enterovirus 71

Virus

Coxsackievirus

Disease

Hand foot mouth disease

Enterovirus

Linguistics

Internal medicine

Pediatrics

Foot (prosody)

Medicine

Eurosurveillance

We report a large-scale outbreak of hand, foot and mouth disease (HFMD) in France. As at 28 September 2021, 3,403 cases have been reported (47% higher than in 2018-19). We prospectively analysed 210 clinical samples; 190 (90.5%) were enterovirus-positive. Most children presented with atypical HFMD. Coxsackievirus (CV)A6 (49.5%; 94/190) was predominant; no enterovirus A71 was detected. Dermatological and neurological complications of HFMD justify prospective syndromic and virological surveillance for early detection of HFMD outbreaks and identification of associated types.

A large-scale outbreak of hand, foot and mouth disease, France, as at 28 September 2021