HIV-1 genetic diversity and natural polymorphisms of the integrase gene in integrase inhibitor naive patients in Harare, Zimbabwe.

BACKGROUND Previously used as part of salvage therapy, integrase strand transfer inhibitors (INSTIs) have become part of the preferred antiretroviral therapy (ART) first-line regimen in most low-to-middle income countries. With the extensive use of dolutegravir in first-line ART, drug resistance mutations to INSTIs are inevitable. Therefore, active monitoring and surveillance of INSTI drug resistance is required. The aim of this study was to...