Metabolomics and molecular networking approaches reveal differential metabolites of Radix Scrophulariae from different geographical origins: Correlations with climatic factors and biochemical compounds in soil

Radix Scrophulariae (RS) is a well-known and frequently used traditional Chinese medicine. Cultivated RS from Zhejiang province is considered to be superior in quality to that from other provinces in China. However, the contribution of geographical origins to differential metabolite production in RS is unclear. In this study, we used ultrahigh-performance liquid chromatography-quadrupole-orbitrap mass spectrometry-based metabolomics and...