3 Rationale and design of the Medical Research Council Precision medicine with Zibotentan in microvascular angina (PRIZE) trial MRI sub-study

Introduction

Microvascular angina is caused by cardiac small vessel disease and dysregulation of the endothelin system is implicated. The chronic elevation of circulating ET-1 in microvascular angina may be influenced by genetic factors. The minor G allele of the non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression of the endothelin 1 gene in human vascular cells, increasing circulating concentrations of ET-1....