Analysis of Soft Tissue Metastases Across Primary Histologies Comparing Radiosensitivity, Immune Infiltration, and Mutational Frequency

The soft tissues are a poorly studied subsite for metastases with unclear treatment paradigms. We hypothesize elucidating differences in these metastases by primary histology may allow for optimization of therapies.We isolated soft tissue metastases with microarray data. A subset also had data from a 1,327-gene targeted exome sequencing assay. An existing radiosensitivity index (RSI) was used to estimate intrinsic radiosensitivity, where higher...