Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.

Rationale null Fibrotic hypersensitivity pneumonitis (fHP) is an interstitial lung disease caused by sensitization to an inhaled allergen. null Objectives null We aimed to identify the molecular determinants associated with progression of fibrosis. null Methods null Nine fHP explant lungs and six unused donor lungs (as controls) were systematically sampled (4 samples/lung). According to microCT measures, fHP cores were clustered into a mild,...