H2S treatment improves protective effect of MSC-derived exosomes upon of renal ischemia/reperfusion fibrosis by suppressing inflammatory signaling of TGF-β and NF-kB as well as ROS generation

Introduction H2S has been reported to participate in renal I/R fibrosis-associated signaling pathways. In this study, the authors hypothesized that the preconditioning with H2S could boost the effect of exosomes in the therapy of renal I/R fibrosis. Material and methods Real-time PCR and Western blot was performed to analyze the gene and protein expression of Nrf2, NF-κB, TGF-β, α-SMA, and Col2 (Collagen Type II) in distinct conditions. H&E...