Toxoplasma gondii UBL–UBA shuttle proteins regulate several important cellular processes

Toxoplasma gondii is an obligate intracellular apicomplexan parasite causing lethal diseases in immunocompromised patients. UBL–UBA shuttle proteins (DDI1, RAD23, and DSK2) are important components of the ubiquitin-proteasome system. By degrading ubiquitinated proteins, UBL–UBA shuttle proteins regulate many cellular processes. However, the specific processes regulated by UBL–UBA shuttle proteins remain elusive. Here, we revealed that the...