Therapeutic Actionability of Circulating Cell-Free DNA Alterations in Carcinoma of Unknown Primary

Issue: 5, Pages: 1687 - 1698
Published: Nov 1, 2021
Abstract
PURPOSE Cancer of unknown primary (CUP) is a metastatic disease with unidentifiable primary tumor. Somatic alterations can be assessed noninvasively via liquid biopsies interrogating cell-free DNA (cfDNA). METHODS We evaluated 1,931 patients with CUP with a cfDNA next-generation sequencing panel (73-74 genes). RESULTS Overall, 1,739 patients (90%) had ≥ 1 cfDNA alteration. We then explored alteration actionability (per the levels of evidence...
Paper Details
Title
Therapeutic Actionability of Circulating Cell-Free DNA Alterations in Carcinoma of Unknown Primary
Published Date
Nov 1, 2021
Journal
Issue
5
Pages
1687 - 1698
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