Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers

Volume: 69, Issue: 11, Pages: 1054 - 1060
Published: Nov 1, 2021
Abstract
In the evaluation of the druggability of candidate compounds, it was vital to predict the oral bioavailability of compounds from apparent permeability (Papp) across Caco-2 cell-culture model of intestinal epithelium cultured on commercial transwell plate inserts. The study was to investigate the transport characteristics and permeability of FL118 (10, 11-Methylenedioxy-20(S)-camptothecin) derivatives 7-Q6 (7-(4-Ethylphenyl)-10,...
Paper Details
Title
Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers
Published Date
Nov 1, 2021
Journal
Volume
69
Issue
11
Pages
1054 - 1060
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