Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis

Introduction Many diseases of adulthood are associated with a woman’s age at menarche. Genetic variation affects age at menarche, but it remains unclear whether in women of African ancestry the timing of menarche is regulated by genetic variants that were identified in predominantly European and East Asian populations. Methods We explored the genetic architecture of age at menarche in 3145 women of African ancestry who live in the USA, Barbados...