Current status of beta‐thalassemia and its treatment strategies

Thalassemia is an inherited hematological disorder categorized by a decrease or absence of one or more of the globin chains synthesis. Beta-thalassemia is caused by one or more mutations in the beta-globin gene. The absence or reduced amount of beta-globin chains causes ineffective erythropoiesis which leads to anemia.Beta-thalassemia has been further divided into three main forms: thalassemia major, intermedia, and minor/silent carrier. A more...