Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages
Abstract
Macrophages play an important role in maintaining tissue homeostasis, from regulating the inflammatory response to pathogens to resolving inflammation and aiding tissue repair. The surfactant protein A (SP-A) receptor SP-R210 (MYO18A) has been shown to affect basal and inflammatory macrophage states. Specifically, disruption of the longer splice isoform SP-R210L/MYO18Aα renders macrophages hyper-inflammatory, although the mechanism by which this...
Paper Details
Title
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages
Published Date
Nov 1, 2021
Journal
Volume
226
Issue
6
Pages
152150 - 152150
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