Tumour microenvironment-responsive nanoplatform based on biodegradable liposome-coated hollow MnO₂ for synergistically enhanced chemotherapy and photodynamic therapy

Existing therapeutic efficacy of chemotherapy and photodynamic therapy (PDT) is always affected by some resistance factors from tumour environment (TME), such as hypoxia and the antioxidant defense system.This study aims at developing a cascaded intelligent multifunctional nanoplatforms to modulate the TME resistance for synergistically enhanced chemo- and photodynamic therapies.In this study, we synthesised hollow manganese dioxide...