Antidepressant‐like effect of rosmarinic acid during LPS ‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR ‐γ signaling pathway
Abstract
Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, has anti-inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug-likeness and the potential molecular targets to RA. Moreover, it tested the antidepressant-like potential of RA in the lipopolysaccharide (LPS)-induced depression model. RA (MW = 360.31 g/mol) meets the criteria of both Lipinski's rule of five and the Ghose...
Paper Details
Title
Antidepressant‐like effect of rosmarinic acid during LPS ‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR ‐γ signaling pathway
Published Date
Oct 28, 2021
Journal
Volume
35
Issue
12
Pages
6974 - 6989
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