Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain
Volume: 227, Pages: 113956 - 113956
Published: Jan 1, 2022
Abstract
We report a series of compounds 1-17 derived from the antiepileptic drug Sulthiame (SLT) from which both the benzenesulfonamide and the sultam moiety were retained. All compounds were tested in vitro for their inhibition activity against the human (h) Carbonic Anhydrase (CA; EC 4.2.1.1) I, II, VII, IX and XII isoforms. Among the series, derivatives 1 and 11 showed great enhancement of both inhibition potency and selectivity towards the hCA VII...
Paper Details
Title
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain
Published Date
Jan 1, 2022
Volume
227
Pages
113956 - 113956
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