Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis
Abstract
The bone marrow has emerged as a potentially important target in cardiovascular disease as it generates all leukocytes involved in atherogenesis. In the current study, we evaluated whether a change in bone marrow functionality underlies the increased atherosclerosis susceptibility associated with high-density lipoprotein (HDL) deficiency. We found that HDL deficiency in mice due to the genetic lack of hepatocyte-derived apolipoprotein A1 (APOA1)...
Paper Details
Title
Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis
Published Date
Nov 16, 2021
Journal
Volume
135
Issue
5
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Notes
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