Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands

Volume: 113, Pages: 107129 - 107129
Published: Jan 1, 2022
Abstract
The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treating neuropsychiatric and neurodegenerative disorders, however, to date, no S1R ligand has been approved for therapeutic purposes. We used three potential methods on known and potential S1R ligands to develop an...
Paper Details
Title
Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands
Published Date
Jan 1, 2022
Volume
113
Pages
107129 - 107129
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