Noise-induced hearing loss

Hearing loss

Sensorineural hearing loss

Regeneration (biology)

Biochemistry

Autophagy

Spiral ganglion

Anatomy

Neuroscience

Inner ear

Biology

Apoptosis

Cell biology

Cochlea

Hair cell

Audiology

Noise exposure

Medicine

Frontiers in Cellular Neuroscience

Inner ear hair cells (HCs) and spiral ganglion neurons (SGNs) are the core components of the auditory system. However, they are vulnerable to genetic defects, noise exposure, ototoxic drugs and aging, and loss or damage of HCs and SGNs results in permanent hearing loss due to their limited capacity for spontaneous regeneration in mammals. Many efforts have been made to combat hearing loss including cochlear implants, HC regeneration, gene therapy, and antioxidant drugs. Here we review the role of autophagy in sensorineural hearing loss and the potential targets related to autophagy for the treatment of hearing loss.

Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss