In vivo commensal control of Clostridioides difficile virulence
Abstract
Leveraging systems biology approaches, we illustrate how metabolically distinct species of Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating the pathogen's colonization, growth, and virulence to impact host survival. Gnotobiotic mice colonized with the amino acid fermenter Paraclostridium bifermentans survive infection with reduced disease severity, while mice colonized with the butyrate-producer,...
Paper Details
Title
In vivo commensal control of Clostridioides difficile virulence
Published Date
Nov 1, 2021
Journal
Volume
29
Issue
11
Pages
1693 - 1708.e7
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