SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy.

Volume: 20, Issue: 12, Pages: 2341 - 2351
Published: Oct 12, 2021
Abstract
The SWI/SNF chromatin remodeling complex, via nucleosome topology modulation, regulates transcription. The SMARCA4 (BRG1) subunit codes for the ATPase energy engine of the SWI/SNF complex. SMARCA4 is a tumor suppressor that is aberrant in ∼5% to 7% of human malignancies. Class I SMARCA4 alterations (truncating mutations, fusions, and homozygous deletion) lead to loss of function whereas class II alterations (missense mutations) have a dominant...
Paper Details
Title
SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy.
Published Date
Oct 12, 2021
Volume
20
Issue
12
Pages
2341 - 2351
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.