Mining Clinical Data for Novel Posttraumatic Stress Disorder Medications

Despite the prevalence and negative impact of posttraumatic stress disorder (PTSD), there are few medications approved by the U.S. Food and Drug Administration for treatment, and approved medications do not work well enough. We leveraged large-scale electronic health record data to identify existing medications that may be repurposed as PTSD treatments.We constructed a mechanistic tree of all Food and Drug Administration-approved medications and...