Combination of DNA demethylation and chemotherapy to trigger cell pyroptosis for inhalation treatment of lung cancer
Abstract
Pyroptosis is an inflammation-dependent and self-cascade amplifying type of programmed cell death, serving as an effective means for activating the local immune response and improving the anticancer efficacy. As the effector of pyroptosis, gasdermin-E (GSDME) is silenced in most tumor cells. The gene silencing can be reversed by DNA demethylation, but the systemic side effects and toxicity of chemotherapeutic agents are inevitable. In this work,...
Paper Details
Title
Combination of DNA demethylation and chemotherapy to trigger cell pyroptosis for inhalation treatment of lung cancer
Published Date
Jan 1, 2021
Journal
Volume
13
Issue
44
Pages
18608 - 18615
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Notes
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