Original paper

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

Cell64.50
Volume: 184, Issue: 23, Pages: 5759 - 5774.e20
Published: Nov 1, 2021
Abstract
NLRP6 is important in host defense by inducing functional outcomes including inflammasome activation and interferon production. Here, we show that NLRP6 undergoes liquid-liquid phase separation (LLPS) upon interaction with double-stranded RNA (dsRNA) in vitro and in cells, and an intrinsically disordered poly-lysine sequence (K350-354) of NLRP6 is important for multivalent interactions, phase separation, and inflammasome activation....
Paper Details
Title
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome
Published Date
Nov 1, 2021
Journal
Volume
184
Issue
23
Pages
5759 - 5774.e20
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