Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers
Abstract
Tumor mutational burden (TMB) may be a predictive biomarker of immune checkpoint inhibitor (ICI) responsiveness. Genomic landscape heterogeneity is a well-established cancer feature. Molecular characteristics may differ even within the same tumor specimen and undoubtedly evolve with time. However, the degree to which TMB differs between tumor biopsies within the same patient has not been established.We curated data on 202 patients enrolled in...
Paper Details
Title
Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers
Published Date
Oct 12, 2021
Journal
Volume
13
Issue
1
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