P38.01 p40 and p63 Immunohistochemistry in the Diagnostic Consideration of NUT Carcinoma in the Lung

NUT Carcinoma of the lung is an undifferentiated/poorly differentiated carcinoma characterized by a gene rearrangement in nuclear protein in testis (NUTM1); it has a monomorphic appearance, discrete nucleoli, infiltrating polymorphonuclear cells (PMN) and areas of abrupt keratinization. Immunohistochemical (IHC) staining shows the following profile: anti-NUT with a speckled pattern (>50% of the tumor cells), positive for cytokeratin, occasional...